In a study conducted by Kanazawa University in Japan on mice, sulforaphane was found to help to fight against obesity. The mice were fed a high-fat diet, but half the mice were supplemented with sulforaphane. In the mice that were fed sulforaphane, it was found that the mice had 15 percent less weight gain and 20 percent visceral fat reduction, reduction in the rise of fatty liver and also a drop in blood glucose level.
Additionally, sulforaphane was found to fight obesity by browning of adipocytes to increase energy consumption. An increase in brown adipose tissue could improve insulin sensitivity and plays an important role in bone health and density. In the same study, sulforaphane was found to improve the gut bacterial flora even after having a high-fat diet with associated inflammation of the adipose tissues and liver.
- Naoto Nagata, Liang Xu, Susumu Kohno, Yusuke Ushida, Yudai Aoki, Ryohei Umeda, Nobuo Fuke, Fen Zhuge, Yinhua Ni, Mayumi Nagashimada, Chiaki Takahashi, Hiroyuki Suganuma, Shuichi Kaneko, Tsuguhito Ota. Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. Diabetes, 2017; db160662 DOI: 10.2337/db16-0662